SEBIA CAPI 3 PROTEIN(E) 6
VERY HIGH THROUGHPUT SERUM PROTEIN ELECTROPHORESIS, WITH HIGH RESOLUTION RESULTS
TEST PRESENTATION
Protein electrophoresis is a well-established technique routinely used in clinical laboratories to screen samples to detect protein abnormalities (gammopathies, inflammatory pattern…). Using the CAPILLARYS 3 TERA instruments, the CAPI 3 PROTEIN(E) 6 kit enables the separation of:
- Serum proteins into six major fractions:
- Albumin
- Alpha-1
- Alpha-2
- Beta-1
- Beta-2
- Gamma
CAPILLARYS 3 TERA instruments automatically process the samples to obtain protein profiles for qualitative and quantitative analysis. Direct UV detection provides accurate relative quantification of the individual protein fractions. Profiles are interpreted visually to screen for any pattern abnormalities.
Serum protein electrophoresis is essential to detect and quantify monoclonal components for the diagnosis and monitoring of patients with monoclonal gammopathies (Multiple Myeloma, MGUS, Waldenström disease…).
TEST PRINCIPLE
The CAPI 3 PROTEIN(E) 6 assay is based on the principle of capillary electrophoresis in free solution. Serum proteins are separated in silica capillaries by their electrophoretic mobility and electroosmotic flow at high voltage in an alkaline buffer. Proteins are directly detected during migration by UV absorbance. Each fraction contains one or more proteins.
Two modes are available for manual peak quantification:
- Valley to valley
- Baseline to top
PERFORMANCES
- Throughput: from 100 tests/h for CAPILLARYS 3 TERA stand alone to 300 tests/h with CAPILLARYS 3 TERA MC configuration
- Sensitivity:
- Internal study has demonstrated that a monoclonal protein can be detected at a concentration as low as 19 mg/dL. According to the mobility of the monoclonal component and polyclonal background, the sensitivity may vary.
- Full traceability and positive sample ID for primary tube samples
- Full traceability and reagents management through RFID tags
- Color-coded backlit reagent containers
- Rapid validation via 96 profile mosaic screen
- Large autonomy:
- Samples up to 600 tubes (with tube loader)
- >2.5 hours Protein testing
KIT DESCRIPTION
CAPI 3 PROTEIN(E) 6 (PN 2503) kit content:
- RFID buffer vials
- Filters
Related products and accessories not provided in the kit:
- Quality controls:
- Normal control serum (PN 4785)
- Hypergamma control serum (PN 4787)
- IT/IF control (PN 4788)
- CAPI 3 DISPOSABLES KIT (PN 2580)
- CAPI 3 IMMUNOTYPING (PN 2600)
- FLUIDIL (PN 4587)
- CAPICLEAN CAPILLARYS 3 (PN 2060)
- CAPILLARYS 3 WASH SOLUTION (1) (PN 2062)
- CAPIprotect (2 x 5L) (PN 2061)
COMPATIBLE INSTRUMENTS
CAPILLARYS 3 TERA MC*
CAPILLARYS 3 TERA TLA*
CAPILLARYS 3 OCTA*
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